Adaptation of Borna disease virus to the mouse.
نویسندگان
چکیده
Borna disease virus has been adapted to the mouse, which required at least three passages in rat brains. Genetic specificity as studied with five inbred mouse strains was not evident. Newborn mice inoculated intracerebrally expressed antigen in neurons and remained persistently infected, with up to 10(7) infectious units per gram of brain tissue. Animals infected at different ages developed no disease and had high titres of antibodies.
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ورودعنوان ژورنال:
- The Journal of general virology
دوره 65 ( Pt 10) شماره
صفحات -
تاریخ انتشار 1984